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PHD3 serves as a hypoxic transcriptional coactivator of HIF-1α C-TAD in NP cells in a p300-dependent and PKM2/JMJD5-independent manner. Proposed model of regulation of HIF-1 activity by PHD3 in NP cells. PHD3 serves as a hypoxic coactivator of HIF-1α in NP cells, directly or indirectly promoting HIF-1 enrichment at target loci and activating C-TAD-dependent targets, independent of PKM2/JMJD5. PKM2 in NP cells does not have cofactor function for HIF-1.
