Figure 8.

ChQ, via gustducin, rescues LPS- or RU-486-induced preterm labor better than MgSO₄ and albuterol. A) Mean cumulative labor induced by LPS followed by treatment with saline, ChQ, MgSO₄, or albuterol in WT mice, or followed by treatment with ChQ in Gnat3^−/− mice. LPS (10 µg, i.p.) was administered on d 16. Lines for WT-saline and WT-MgSO₄ are overlapped. P < 0.05 saline vs. ChQ; P < 0.05 saline vs. albuterol; P < 0.01 WT ChQ vs. Gnat3^−/− ChQ; n = 11 for each group and P value from χ² test. B) Mean cumulative labor induced by RU-486 followed by intrauterine administration of saline, ChQ, MgSO₄, or albuterol in WT mice, or followed by treatment with ChQ in Gnat3^−/− mice. RU-486 (150 mg, s.c.) was administered on d 16. Lines for WT-saline and WT-albuterol are overlapped. P < 0.05 saline vs. ChQ, P < 0.05 WT ChQ vs. Gnat3^−/− ChQ; n = 10–11 for each group, χ² test.