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. 2017 Aug 25;7:9503. doi: 10.1038/s41598-017-10336-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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PTEN inhibition exacerbates kidney injury after IRI. (A) Serum creatinine increased markedly in PTEN inhibitor bpV treated mice with IRI. **P < 0.01 vs. Vehicle Sham, ⁺⁺ P < 0.01 vs. bpV IRI, ^## P < 0.01 vs. Vehicle IRI. n = 6 per group. (B) Blood serum urea nitrogen (BUN) increased significantly in bpV treated mice with IRI. **P < 0.01 vs. Vehicle Sham, ⁺⁺ P < 0.01 vs. bpV IRI, ^## P < 0.01 vs. Vehicle IRI. n = 6 per group. (C) Representative photomicrographs of kidney sections stained with hematoxylin and eosin. Scale bar, 50 μm. (D) Quantitative analysis of tubular damage after IRI. *P < 0.05 vs. Vehicle IRI. n = 6 per group.