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. 2017 Aug 25;7:9531. doi: 10.1038/s41598-017-10193-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Diabetes mellitus was induced in Landrace pigs, and 2 × 2-cm wounds were created to observe wound healing. (A) The wound area size of the original type, original type mixed with 5% collagen, original type mixed with 350-ppm silver nanowire, original type mixed with 175-ppm silver nanowire, original type mixed with 5% collagen, 5% chitosan, and 350-ppm silver nanowire, and original type mixed with 5% collagen, 5% chitosan, and 175-ppm silver nanowire at day 0, day 7, day 11, day 18 and day 25. (B) The wound healing area quantitative analysis. (C) A 10th-day tissue section stained with H&E stain and Masson’s trichrome stain. The scale bar is 200 micrometer (D) A 21st-day tissue section stained with H&E stain and Masson’s trichrome stain. The scale bar is 200 micrometer.