Table 1.

Renal hemodynamics data of Protocol 1.

		vehicle	luseogliflozin	Nx -vehicle	Nx-luseogliflozin
MAP (mmHg)	baseline	103 ± 2	98 ± 3	104 ± 2	105 ± 1
	15	103 ± 3	99 ± 3	106 ± 5	113 ± 2
	45	108 ± 2	98 ± 3	102 ± 7	111 ± 4
	75	104 ± 2	97 ± 3	103 ± 3	107 ± 2
	105	104 ± 3	97 ± 2	104 ± 2	100 ± 4
	120	105 ± 3	99 ± 6	96 ± 4	97 ± 3
HR (beats min−1)	baseline	390 ± 8	386 ± 14	373 ± 18	339 ± 13
	15	384 ± 9	385 ± 13	372 ± 25	340 ± 11
	45	417 ± 8	400 ± 8	391 ± 11	358 ± 10
	75	427 ± 7	388 ± 13	381 ± 10	368 ± 13
	105	413 ± 10	369 ± 14	397 ± 16	367 ± 11
	120	418 ± 16	380 ± 10	390 ± 9	381 ± 9
Mean RBF (fold)	baseline	1.00 ± 0.02	1.00 ± 0.04	1.00 ± 0.12	1.00 ± 0.05
	5	0.91 ± 0.01	1.05 ± 0.05	1.00 ± 0.11	0.81 ± 0.11
	10	0.92 ± 0.01	0.96 ± 0.03	1.00 ± 0.11	1.00 ± 0.03
	15	1.03 ± 0.04	1.05 ± 0.05	0.97 ± 0.13	1.01 ± 0.04
	30	1.12 ± 0.13	0.98 ± 0.06	0.94 ± 0.08	1.02 ± 0.06
	60	1.08 ± 0.04	1.00 ± 0.03	0.87 ± 0.06	0.99 ± 0.07
	90	1.11 ± 0.02	0.99 ± 0.04	0.85 ± 0.03	0.89 ± 0.11
	120	1.08 ± 0.05	1.04 ± 0.04	0.81 ± 0.03	0.83 ± 0.14
CrCl (µl min−1 g−1 body weight)	baseline	3.22 ± 0.56	3.32 ± 0.71	5.24 ± 0.40	5.41 ± 0.42
	30	3.99 ± 0.45	4.10 ± 0.54	5.54 ± 0.42	5.97 ± 0.26
	60	3.76 ± 0.25	4.24 ± 0.63	5.48 ± 0.30	5.64 ± 0.29
	90	3.66 ± 0.21	4.14 ± 0.70	5.15 ± 0.40	5.22 ± 0.28
	120	3.75 ± 0.32	4.21 ± 0.76	4.94 ± 0.60	4.91 ± 0.33

MAP, mean blood pressure; HR, heart rate; RBF, renal blood flow; CrCl, creatinine clearance; SD, Sprague-Dawly; Nx, 5/6 nephrectomized SD rats; vehicle, SD rats treated with vehicle; luseogliflozin, SD rats treated with luseogliflozin; Nx-vehicle, 5/6 nephrectomized SD rats treated with vehicle; Nx-luseogliflozin, 5/6 nephrectomized SD rats treated with luseogliflozin. Values are mean ± SEM.