Fig. 5.

Typical values of total paracetamol clearance from the final model for a patient with a procedural analgesia indication and assuming the median urine flow rate (6.5 mL/h) for a a range of body weights at the median postnatal age of 6 days and b a range of postnatal ages at the median body weight of 2.8 kg. Within each bar, typical clearance values for each pathway are shown (from bottom to top)ingray for renal clearance of unchanged parent drug, blue for glucuronidation, green for sulfation, and orange for oxidation