Fig. 6.

Fraction of total paracetamol clearance accounted for by glucuronidation, sulfation, oxidation, and renal clearance of unchanged parent drug. Fractional clearances for each subject (open black circles) are shown vs. the significant covariates current body weight (a) and postnatal age (b). The dashed red lines depict quasibinomial fits of the data, and the shaded gray regions depict 95 % confidence intervals surrounding the regression curves. Fractional clearances were calculated from individual formation (hepatic) clearance estimates for paracetamol-glucuronide, paracetamol-sulfate, and the combined oxidative pathway metabolites (paracetamol-cysteine and paracetamol-N-acetylcysteine) and from the median individual estimates for renal clearance of unchanged paracetamol