Table 3.

Correlation in between-subject variability for the final model of paracetamol and its metabolites in neonates^a

Parameter	CLfG	CLfS	CLfO	VP	VG	VS	VO	CLRP
CLfS	0.37 [0.036 to 0.69]
CLfO	0.49 [0.16 to 0.80]	0.054 [−0.33 to 0.54]
VP	0.35 [− to 0.65]	−0.20 [−0.59 to 0.36]	0.18 [−0.38 to 0.67]
VG	0.60 [0.14 to 0.83]	0.032 [−0.30 to 0.50]	0.42 [−0.0083 to 0.75]	0.43 [−0.50 to 0.75]
VS	0.19 [−0.35 to 0.77]	0.64 [0.10 to 0.83]	−0.10 [−0.50 to 0.45]	0.28 [−0.51 to 0.57]	0.13 [−0.31 to 0.63]
VO	−0.10 [−0.42 to 0.59]	−0.40 [−0.72 to 0.37]	0.44 [−0.24 to 0.75]	0.53 [−0.37 to 0.85]	0.15 [−0.14 to 0.57]	−0.14 [−0.47 to 0.44]
CLRP	0.041 [−0.46 to 0.51]	−0.033 [−0.41 to 0.49]	−0.14 [−0.51 to 0.43]	0.20 [−0.44 to 0.72]	−0.036 [−0.59 to 0.42]	−0.0082 [−0.55 to 0.60]	−0.11 [−0.65 to 0.59]
CLRG,CLRS, CLROb	0.52 [0.29 to 0.73]	0.73 [0.35 to 0.91]	0.28 [−0.37 to 0.68]	0.22 [−0.25 to 0.57]	0.23 [−0.16 to 0.57]	0.46 [−0.065 to 0.71]	−0.30 [−0.72 to 0.55]	0.33 [−0.068 to 0.74]

CL_fG, CL_fS, and CL_fO represent, respectively, formation (hepatic) clearances for paracetamol-glucuronide, paracetamol-sulfate, and the oxidative pathway metabolites; V_P, V_G, V_S, and V_O represent, respectively, volumes of distribution for paracetamol, paracetamol-glucuronide, paracetamol-sulfate, and the oxidative pathway metabolites; CL_RP, CL_RG, CL_RS, and CL_RO represent, respectively, renal clearances for unchanged paracetamol, paracetamol-glucuronide, paracetamol-sulfate, and the oxidative pathway metabolites

^aData are presented as: correlation point estimate from the final model fit [bootstrap 95 % confidence interval]. Bootstrap success rate was 77 % (n = 153 out of 200)

^bCorrelations in between-subject variability for CL_RG, cl_RS, and CL_RO were observed to be high and were fixed to one