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. Author manuscript; available in PMC: 2017 Aug 28.
Published in final edited form as: Clin Pharmacokinet. 2016 Nov;55(11):1395–1411. doi: 10.1007/s40262-016-0408-1

Table 4.

Correlation in proportional residual unexplained variability for the final model of paracetamol and its metabolites in neonatesa

Plasma compartments
Urine compartments
Paracetamol Paracetamol-glucuronide Paracetamol-sulfate Paracetamol Paracetamol-glucuronide Paracetamol-sulfate
Paracetamol-glucuronide   0.38 [0.19–0.54]   0.58 [0.43–0.72]
Paracetamol-sulfate   0.56 [0.31–0.72]   0.84 [0.55–0.98]   0.51 [0.37–0.72]   0.94 [0.92–0.98]
Oxidative pathway metabolites   0.29 [0.10–0.50]   0.57 [0.30–0.76]   0.59 [0.28–0.88]   0.55 [0.39–0.70]   0.90 [0.87–0.93]   0.92 [0.89–0.96]
a

Data are presented as: correlation point estimate from the final model fit [bootstrap 95 % confidence interval]. Bootstrap success rate was 77 % (n = 153 out of 200)