Table 1.

Characteristics of Patients with Recurrent Stage I–III Breast, Colorectal, and Lung Cancer by Data Source: Column Percents for Different Subgroups

	Breast N=505	Colorectal N=670	Lung N=478
Age at recurrence
Median (25th, 75th percentile)	60 (50–72)	68 (58–77)	69 (61–75)
21–54	35	17	10
55–69	34	38	44
≥70	31	46	47
Sex
Male	0	56	56
Female	100	44	44
Race/Ethnicity
Non-Hispanic white	82	70	78
Non-White or Hispanic	8	23	18
Unknown	10	7	4
Marital status*
Married/living with partner	57	60	61
Not married	27	32	34
Unknown	15	7	5
Smoking status**
Never	52	42	9
Former smoker	29	38	61
Current smoker	14	10	19
Unknown	5	10	11
Annual income (US$)‡
<40,000	11	26	35
40,000 to <60,000	29	21	21
≥60,000	54	38	28
Unknown	6	15	16
Data source
CRN	100	54	42
CanCORS	0	46	58
Modified Charlson comorbidity index||
0	73	56	34
1	17	26	33
2+	10	18	33
Year of recurrence
2000–2003	13	12	9
2004–2006	26	55	59
2007–2009	29	20	22
2010–2012	31	13	10
Stage of primary diagnosis***
I	29	10	53
II	42	32	25
III	30	58	22
Primary cancer hormone receptor status
HR negative	17	NA	NA
HR positive	40	NA	NA
HR unknown	43	NA	NA
Primary cancer grade††
Low/Intermediate	45	74	43
High/Undifferentiated	52	23	48
Unknown	3	2	9
Therapy for the primary cancer‡‡
Chemotherapy	71	66	41
Radiation therapy	67	24	25
Time from primary to recurrence	Months	Months	Months
Median (25th, 75th percentile)	32 (18, 47)	16 (10, 27)	14 (9, 25)
Mean (SD)	37 (26)	21 (16)	20 (17)
Type of recurrence
Local	19	7	7
Distant or regional	81	93	93
Therapy for recurrence‡‡‡
Chemotherapy	58	40	33
Radiation therapy	31	7	26

Abbreviations: CRN = Cancer Research Network; CanCORS = Cancer Care Outcomes Research & Surveillance Consortium; SD = standard deviation; HR = hormone receptor; NA = Not applicable.

^*Marital status was obtained from the Virtual Data Warehouse (VDW) tumor registries for CRN cohort and from patient/surrogate reports for the CanCORS cohort.

^**Smoking status was obtained from the VDW social history files for the CRN cohort and from patient/surrogate reports at approximately four months after initial diagnosis for the CanCORS cohort.

^‡Income data were obtained from block-level Census data in the VDW for the CRN cohort and from patient/surrogate reports for the CanCORS cohort.

^||Comorbidity Index derived using methods developed by Charlson, Katz and colleagues^[15–17], excluding cancer diagnoses.

^***Stage based on AJCC version 6 or 7; Stage IIIb lung cancer patients were excluded.

^††Low/Intermediate includes grades 1–2; High/Undifferentiated included grades 3–4.

^‡‡Not mutually exclusive. CRN patients were classified as receiving therapy if it was documented in either the tumor registry or in the VDW within 1 year after initial diagnosis. CanCORS patients were classified as receiving therapy if it was documented in the medical record abstraction within 1 year after initial diagnosis.

^‡‡‡Not mutually exclusive. Among patients who survived at least 3 months after recurrence. CRN and CanCORS patients were classified as receiving therapy if it was documented, respectively, in the VDW or in the medical record abstraction within 3 months after recurrence.