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. 2017 Aug 19;23:4004–4013. doi: 10.12659/MSM.902770

Figure 6.

Figure 6

Effect of apigenin on the expressions of acetylated H3, acetylated H4, BDNF and pCREB in the hippocampus of rats after MCAO. (A) Western blot analysis of protein levels of acetylated H3 and acetylated H4, BDNF and pCREB in the hippocampus. (B) Effect of apigenin on the protein expressions of acetylated H3 and acetylated H4 in the hippocampus. Data are expressed as mean ±SEM and were analyzed by one-way ANOVA (n=3). ** p<0.01 vs. sham group, * p<0.05 vs. sham group, ## p<0.01 vs. model group, # p<0.05 vs. model group, @ p<0.05 vs. NaB group. (C) Effect of apigenin on BDNF mRNA and protein expressions in the hippocampus. Data are expressed as mean ±SEM and were analyzed by one-way ANOVA (n=3). ** p<0.01 vs. sham group, * p<0.05 vs. sham group, ## p<0.01 vs. model group, #p < 0.05 vs. model group, @ p<0.05 vs. NaB group, && p<0.01 vs. apigenin (20 mg/kg) group. (D) Effect of apigenin on pCREB protein expression in the hippocampus. Data are expressed as mean ±SEM and were analyzed by one-way ANOVA (n=3). ** p<0.01 vs. sham group, # p<0.05 vs. model group.