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Targeting strategy to insert transgene into Rosa26 locus. Conditional transgene expressed from the CAG promoter upon Cre-mediated recombination (a). To monitor expression of the transgene in vivo a 2A-GFP cassette can be cloned downstream of the transgene of interest (b). 2A is a self-cleaving peptide, having high cleavage efficiency between genes upstream and downstream of it
