Skip to main content
. Author manuscript; available in PMC: 2018 Aug 15.
Published in final edited form as: Cell Rep. 2017 Aug 15;20(7):1681–1691. doi: 10.1016/j.celrep.2017.07.050

Figure 5.

Figure 5

Molecular dynamics analyses of unliganded 3F8. Worm plots of (A) germline 3F8 and (B) affinity mature 3F8 illustrate a relatively rigid germline structure that loosens slightly during affinity maturation. CDR loops are labeled and residue mutations between germline and affinity mature are shown in stick representation. Histograms of RMSD distribution from the starting conformation for CDR loops during the simulations. Light chain CDRs 1–3 (Figures C–E respectively) and heavy chain CDRs 1–3 (Figures F–H respectively) illustrate the propensity of mature CDRs to explore conformational space more liberally. See also Figure S7 and Table S4.