Figure 2. Evaluation of motor activity/forced ambulation using the rotarod test. Group PROF25: administration of prophylactic 25 mg/kg of strontium ranelate (SrRan) 4 weeks prior to the induction of monoiodoacetate (MIA)-induced osteoarthritis (OA); Groups SR25 and SR50 (treatment groups) received 25 mg/kg and 50 mg/kg of SrRan, respectively, after OA induction for a period of 4 weeks; SAL: MIA-induced OA receiving only saline; Control group: no treatment and no OA induction. Results are reported as means±SD. P<0.05 between groups PROF25, SR25 and SR50, and Control; P>0.05 between those groups and SAL (one-way ANOVA, followed by the Bonferroni’s test).