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Model showing the interplay between PHLPP1 and RNF41 in regulation of SGT1 at kinetochores. PHLPP1 dephosphorylates SGT1 and maintains stable SGT1 at kinetochores. In the absence of PHLPP1, E3 ligase RNF41 associates with phosphorylated SGT1 and promotes its degradation and thereby limits SGT1 availability at kinetochores.
