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. 2017 Aug 23;9:279. doi: 10.3389/fnagi.2017.00279

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Copyright © 2017 Mai, Zhong, Chen, Peng, Wu, Zhang, Ouyang and Ning.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) From left to right, the images represent the rich-club connection, feeder connection and local connection. Rich-club included bilateral olfactory, cingulum_post, amygdala, putamen, and pallidum. The rich-club connections are colored in yellow, and the feeder and local connections are colored in gray. (B) From left to right, the graphs represent group differences in rich-club connective average connective strength, feeder connective average connective strength, and local connective average connective strength in a normalized weight probability connective network among 3 groups (^*P < 0.05 in LSD post hoc comparisons). (C) A Pearson correlation between subnetwork average connective strength and cognitive function in LLD groups (LLD-MD+LLD-IM) (adjust with HDRS; ^*P < 0.05; ^**P < 0.05/3). The nodes and connections were mapped using BrainNet Viewer software (http://www.nitrc.org/projects/bnv/).