Table 1.
Inactivated Vaccines for Patients With IBD
| Influenza: All patients with IBD should be vaccinated seasonally with the intramuscular/intradermal inactivated influenza vaccine prior to starting immunosuppressive therapy. |
| Pneumococcal pneumonia: All patients with IBD should be vaccinated once with the PCV13 followed by the PPSV23 (first dose after 8 weeks if immunocompromised, or after ≥1 year if immunocompetent; second PPSV23 dose after 5 years; and third dose after 65 years of age). If previously vaccinated with the PPSV23, then the PCV13 should be administered at least 1 year after the PPSV23 in both immunocompromised and immunocompetent adults. |
| Hepatitis A: Check hepatitis A immune status at the patient’s initial visit. If nonimmune to hepatitis A, vaccinate the patient with a 2-dose series (0 months and 6-12 months). |
| Hepatitis B: Check hepatitis B immune status at the patient’s initial visit. If nonimmune to hepatitis B, vaccinate the patient with a 3-dose series (0 months, and 1 and 6 months after first dose) and recheck titers 1 to 2 months after last vaccination. If the patient remains nonimmune, offer booster with a double dose of hepatitis B vaccine or offer combined hepatitis A/B vaccination. |
| Human papilloma virus: All male and female IBD patients between the ages of 11 and 26 years should be vaccinated with the human papilloma virus vaccine. |
| Meningococcus: Patients with IBD should be vaccinated with the meningococcal vaccine according to standard ACIP recommendations for the general population. |
| Td/TDap: All patients with IBD should be vaccinated with Td every 10 years. TDap should be substituted once for the Td vaccine to provide additional coverage for pertussis. |
ACIP, Advisory Committee on Immunization Practices; IBD, inflammatory bowel disease; PCV13, 13-valent pneumococcal conjugate vaccine; PPSV23, 23-valent pneumococcal polysaccharide vaccine; Td, tetanus and diphtheria; TDap, tetanus, diphtheria, and acellular pertussis.
Reproduced from Reich J, Wasan SK, Farraye FA. Vaccinating patients with inflammatory bowel disease. Gastroenterol Hepatol (N Y). 2016;12(9):540-546.