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. 2017 May 19;12(3):249–261. doi: 10.2217/rme-2016-0141

Figure 2. . Graft Histomorphometry.

Figure 2. 

Unseeded scaffolds were implanted in PDGF knockout mice and wild-type controls for 2 weeks. Representative hematoxylin and eosin stained tissue sections of stenotic (A, D) and patent (B, E) grafts from wild-type (A, B) and PGDF-KO (knockout) (D, E) mice (scale bar = 500 μm). High magnification images of representative patent TEVGs (tissue-engineered vascular grafts) from each group (C, F) demonstrate increased neointimal tissue formation in the WT mice (scale bar = 50 μm). Histomorphometry of all TEVG samples compared TEVG area, lumen area, remaining polymer area and neotissue area (G). PGDF-KO grafts were found to have greater TEVG area, more remaining polymer and reduced neotissue area compared with WT controls (H; *p < 0.05).

KO: Knockout; TEVG: Tissue-engineered vascular graft; WT: Wild-type.