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. 2017 Aug 21;10:1973–1989. doi: 10.2147/JPR.S132682

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© 2017 Pajak et al. This work is published and licensed by Dove Medical Press Limited

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Outline of the experiment design.

Notes: Rats were monitored for OA-related pain symptoms by DWB before MIA injection and every second day after the procedure during the 28-day period of the experiment. Gene expression analysis by qPCR was conducted on joint tissue samples collected on days 2, 7, 14, 21 and 28 post-MIA injection. For proteomic assessment, the joint tissue samples were collected before MIA injection and 2, 7, 14, 21 and 28 days after OA induction and processed for WB.

Abbreviations: DWB, dynamic weight bearing; MIA, monoiodoacetate; OA, osteoarthritis; qPCR, quantitative polymerase chain reaction; WB, Western blotting.