Table S2.

Correlation matrix for DWB data and expression levels

		Δ weight (%m) vs. Sox9	Δ weight (%m) vs. Comp	Δ weight (%m) vs. Mmp3	Δ weight (%m) vs. Mmp9	Δ weight (%m) vs. Mmp13	Δ weight (%m) vs. Timp1
weight (%m) vs gene expression	r	0.05944	−0.04753	−0.09938	−0.09954	0.4122	0.2161
	95% confidence interval	−0.8685 to 0.8949	−0.8924 to 0.8714	−0.9026 to 0.8582	−0.9026 to 0.8582	−0.7389 to 0.9493	−0.8232 to 0.9225
	R square	0.003533	0.002259	0.009877	0.009908	0.1699	0.04668
	P (one-tailed)	0.4622	0.4698	0.4368	0.4367	0.2452	0.3635
	p-value summary	ns	ns	ns	ns	ns	ns
	Significant? (α = 0.05)	No	No	No	No	No	No
	Number of XY pairs	5	5	5	5	5	5
		Δ weight (%m) vs. Cnr1	Δ weight (%m) vs. Cnr2	Δ weight (%m) vs. Faah	Δ weight (%m) vs. Napepld	Δ weight (%m) vs. Alox15	Δ weight (%m) vs. Ptsg2
	r	−0.5224	−0.03812	−0.1887	0.005075	0.3837	0.3332
	95% confidence interval	−0.9615 to 0.6677	−0.8905 to 0.8736	−0.9182 to 0.8322	−0.8812 to 0.8835	−0.7539 to 0.9458	−0.7778 to 0.9394
	R square	0.2729	0.001453	0.03561	2.58E-05	0.1472	0.111
	P (one-tailed)	0.1832	0.4757	0.3806	0.4968	0.2619	0.2919
	p-value summary	ns	ns	ns	ns	ns	ns
	Significant? (α = 0.05)	No	No	No	No	No	No
	Number of XY pairs	5	5	5	5	5	5
weight (%m) vs gene expression		Δ weight (%m) vs. Timp2	Δ weight (%m) vs. Gde1	Δ weight (%m) vs. Plcb1	Δ weight (%m) vs. Alox12	Δ weight (%m) vs. Pla2g2a	Δ weight (%m) vs. TIMP1
	r	0.04022	0.5007	0.3764	0.399	0.2813	0.2321
	95% confidence interval	−0.8731 to 0.8909	−0.6837 to 0.9593	−0.7575 to 0.9449	−0.7460 to 0.9477	−0.7995 to 0.9322	−0.8177 to 0.9250
	R square	0.001618	0.2507	0.1417	0.1592	0.07911	0.05387
	P (one-tailed)	0.4744	0.1951	0.2662	0.2529	0.3233	0.3536
	p-value summary	ns	ns	ns	ns	ns	ns
	Significant? (α = 0.05)	No	No	No	No	No	No
	Number of XY pairs	5	5	5	5	5	5
		Δ weight (%m) vs. SOX9	Δ weight (%m) vs. COMP	Δ weight (%m) vs. MMP3	Δ weight (%m) vs. MMP2	Δ weight (%m) vs. MMP9	Δ weight (%m) vs. MMP13
	r	0.5237	0.6089	0.07722	0.9253	−0.4425	0.3316
	95% confidence interval	−0.6667 to 0.9617	−0.5909 to 0.9701	−0.8640 to 0.8984	0.2340 to 0.9952	−0.9528 to 0.7216	−0.7785 to 0.9392
	R square	0.2743	0.3707	0.005963	0.8562	0.1958	0.11
	P (one-tailed)	0.1825	0.1379	0.4509	0.0121	0.2278	0.2928
	p-value summary	ns	ns	ns	*	ns	ns
	Significant? (α = 0.05)	No	No	No	Yes	No	No
	Number of XY pairs	5	5	5	5	5	5
		Δ weight (%m) vs. CB1	Δ weight (%m) vs. CB2	Δ weight (%m) vs. FAAH	Δ weight (%m) vs. NAPE- PLD	Δ weight (%m) vs. 15LOX2	Δ weight (%m) vs. COX2
	r	0.8844	0.5222	0.8038	−0.8895	0.364	0.7891
	95% confidence interval	0.009190 to 0.9924	−0.6679 to 0.9615	−0.2701 to 0.9865	−0.9927 to -0.03346	−0.7636 to 0.9434	−0.3071 to 0.9854
	R square	0.7821	0.2726	0.6461	7.91E-01	0.1325	0.6226
	P (one-tailed)	0.0232	0.1834	0.0506	0.0217	0.2735	0.0563
	p-value summary	*	ns	ns	*	ns	ns
	Significant? (alpha = 0.05)	Yes	No	No	Yes	No	No
	Number of XY Pairs	5	5	5	5	5	5

Notes: Correlation matrix for DWB data and expression levels. Pearson correlation analysis has been performed: 1) between behavioral effects and alterations in gene expression levels, and 2) between behavioral effects and alterations in protein expression levels (grey shading); p<0.05 has been considered significant.

Abbreviations: COMP, cartilage oligomeric matrix protein; MMP, matrix metalloproteinase; TIMP, tissue inhibitors of metalloproteinase; FAAH, fatty acid amide hydrolase; NAPE-PLD, N-acyl phosphatidylethanolamine phospholipase D.