Appendix Table 1.
Recommendations to the ethics review board and personal preferences on how to obtain consent.
| Definitely Written Consent % (95% CI) | Probably Written Consent % (95% CI) | Probably Alternative Option % (95% CI)* | Definitely Alternative Option % (95% CI)* | |
|---|---|---|---|---|
| Recommendation to ethics review board | ||||
| Overall (N = 2128) | 42.0 (39.8 – 44.3) | 22.4 (20.6 – 24.4) | 22.0 (20.2 – 24.0) | 13.5 (12.0 – 15.2) |
| Drug RCT | ||||
| General Notification (n = 503) | 45.4 (40.8 – 50.0) | 26.1 (22.3 – 30.3) | 18.1 (14.6 – 22.3) | 10.4 (7.9 – 13.5) |
| Verbal Consent (n = 558) | 41.0 (36.7 – 45.4) | 21.5 (18.0 – 25.4) | 23.3 (19.6 – 27.3) | 14.3 (11.4 – 17.7) |
| Dose Timing RCT | ||||
| General Notification (n = 544) | 36.8 (32.6 – 41.1) | 23.6 (19.9 – 27.7) | 26.7 (22.9 – 31.0) | 13.0 (10.2 – 16.4) |
| Verbal Consent (n = 523) | 45.6 (41.1 – 50.2) | 18.8 (15.5 – 22.5) | 19.5 (16.1 – 23.4) | 16.2 (13.0 – 19.9) |
| Personal preference | ||||
| Overall (N = 2129) | 47.7 (45.5 – 50.0) | 19.7 (18.0 – 21.5) | 18.8 (17.0 – 20.7) | 13.8 (12.3 – 15.4) |
| Drug RCT | ||||
| General Notification (n = 503) | 52.4 (47.8 – 57.0) | 19.2 (15.9 – 23.1) | 19.3 (15.7 – 23.6) | 9.1 (6.9 – 11.9) |
| Verbal Consent (n = 558) | 43.6 (39.3 – 48.0) | 20.9 (17.5 – 24.8) | 19.2 (15.8 – 23.0) | 16.3 (13.3 – 19.8) |
| Dose Timing RCT | ||||
| General Notification (n = 545) | 45.5 (41.1 – 50.0) | 21.8 (18.3 – 25.8) | 19.7 (16.2 – 23.6) | 13.1 (10.3 – 16.4) |
| Verbal Consent (n = 523) | 50.2 (45.7 – 54.7) | 16.7 (13.6 – 20.3) | 17.0 (13.9 – 20.7) | 16.1 (13.1 – 19.6) |
*
General notification or verbal consent was given as the alternative option based on the arm of the study.