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. Author manuscript; available in PMC: 2018 Mar 8.
Published in final edited form as: Sci Transl Med. 2017 Mar 8;9(380):eaaf5347. doi: 10.1126/scitranslmed.aaf5347

Fig. 7. Evaluation of semisynthetic glycoconjugates as vaccine candidates against ST8 in rabbits.

Fig. 7

(A) Immunization strategy. Rabbits (n = 3 per group) were s.c. immunized 3 times with CRM197 glycoconjugates or CRM197. Serum was collected at regular intervals. (B) Immune responses of one representative rabbit per group at day 35, as assessed by glycan microarray. (C–F) Immune response against ST8 CPS as assessed by polysaccharide ELISA. (C) Time course of ST8 CPS binding by rabbit sera (1:1600 dilutions). Data are mens ± SD of n = 3 rabbits per group. (D) Evaluation of ST8 CPS binding by rabbit sera at day 35 (1:1600 dilution). Data are medians ± range of n = 3 rabbits per group. P values are determined by one-tailed Mann-Whitney U test. (E) ST8 CPS binding of rabbit sera at different dilutions. Data are means ± SD of n = 3 rabbits per group. (F) Endpoint titers of rabbit sera (n = 3 per group) against ST8 CPS.