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. Author manuscript; available in PMC: 2018 Sep 1.
Published in final edited form as: J Invest Dermatol. 2017 May 24;137(9):1842–1849. doi: 10.1016/j.jid.2017.05.011

Figure 1.

Figure 1

Amlexanox induces full length type VII collagen synthesis in RDEB patient derived cells. Keratinocytes (a and b) and fibroblasts (c) isolated from different RDEB patients were treated with 250 μM amlexanox (A) or gentamicin 1 mM (G). Expression of type VII collagen after treatment was compared to normal human keratinocytes or fibroblasts (NHK or NHF) using Western blotting. For optimization of detection, the amount of protein loaded from RDEB keratinocytes (not fibroblasts) was twice the amount of protein loaded from control cells. Levels of type VII collagen expression were quantified in image J relative to β-actin and non-treated controls (NT). Graph shows protein levels as a percentage of normal cells.