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A single nucleotide substitution restores editing. (A) Base-pairing of ND7 gRNA and mRNA transcripts. The asterisk indicates the location of a single nucleotide substitution that can restore in vitro editing. The remaining features are as described for Figure 1. (B) The primer extension assay was performed to detect U-insertions within the first ND7 editing site. The extension was terminated by the addition of ddC.
