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. Author manuscript; available in PMC: 2018 May 1.
Published in final edited form as: Mayo Clin Proc. 2017 May;92(5):838–850. doi: 10.1016/j.mayocp.2017.02.003

Figure 1.

Figure 1

Approach to Evaluation of a Patient with a Monoclonal Protein identified in conjunction with Peripheral Neuropathy

*Based on history, physical examination, and if appropriate, laboratory and radiographic testing

†This group includes patients with multiple myeloma who have concurrent peripheral neuropathy. These patients need therapy to eradicate the neoplastic clone due to the nature of the malignancy in contrast to patients with monoclonal gammopathy of undetermined significance in whom establishing a causal relationship between neuropathy and the monoclonal protein is critical for therapeutic purposes.

POEMS, polyneuropathy, osteosclerotic myeloma, endocrinopathy, monoclonal protein, skin changes.