Dialysate dopamine concentrations in medial prefrontal cortex (mPFC) during home cage baseline, wait, drink and postdrink periods for the sucrose and handling controls along with rats trained to drink 10S10E. For clarity, only group comparisons are shown on the figure as follows. *Significant difference between the 10S10E group compared with either the 10S or handling groups during the baseline and wait periods. #Drink and postdrink period dopamine concentrations were significantly different in 10S compared with either the 10S10E or handling groups. Not indicated in the figure are significant increases in dopamine at the first sample during the wait period compared with the remaining samples. Similarly, there was a significant increase in dopamine during the first drink sample compared with the remaining drink and postdrink samples. Overall significant main effects of time and a group-by-time interaction occurred. Data represented as mean ±SEM for most points, but selected error bars are omitted for clarity (n =9 for each group). 10S10E = 10% sucrose + 10% ethanol, 10S = 10% sucrose.