Table 2.
| |||||
---|---|---|---|---|---|
Cmpd. | X | ED50(nM)a | Cmpd. | X | EC50(nM)a |
10a | H | 97 | 10o | 2'Cl | 1300 |
10b | 3'-Cl, 4'-OMe | 53 | 10p | 3'-Cl | 162 |
10c (N-Me) | 3'-Cl, 4'-OMe | >5000 | 10q | 4'-C | 497 |
10d | 3'-CN | 50 | 10r | 3'-OCF3 | 57 |
10e (cis) | 3'-CN | 207 | 10s | 4'-OCF3 | 1022 |
10f (N-Me) | 3'-CN | 4115 | 10t | 3'-CF3 | 136 |
10g | 2'-CN | 1426 | 10u | 3'-CN, 4'-OMe | 29 |
10h | 4'-CN | 1134 | 10v | 3'-CN, 4'-F | 19 |
10i | 4'-OMe | 65 | 10w (cis) | 3'-CN, 4'-F | 146 |
10j | 3'-OMe | 190 | 10x | 3'-CN, 4'-Cl | 157 |
10k | 2'-OMe | 943 | 10y | 3'-CN, 5'-F | 58 |
10l | 2'-F | 475 | 10z | 3'-CN, 5'-Cl | 25 |
10m | 3'-F | 89 | 10aa | 3'-CN, 5'-CN | 1104 |
10n | 4'-F | 56 |
Concentration causing 50% reduction in growth of P falciparum 3D7 co-cultured with human erythrocytes; values shown are from two independent experiments done in triplicate.