Skip to main content
. Author manuscript; available in PMC: 2017 Sep 8.
Published in final edited form as: J Med Chem. 2016 Aug 25;59(17):7950–7962. doi: 10.1021/acs.jmedchem.6b00752

Table 3.

Modifications at C-3.

graphic file with name nihms847875u4.jpg
Cmpd. Y EC50 (nM)a Solubilityb Cmpd. Y EC50 (nM)a Solubilityb
11a graphic file with name nihms847875t13.jpg 474 13 ± 1 11n graphic file with name nihms847875t14.jpg 52 ND
11b graphic file with name nihms847875t15.jpg >5000 <1 11o graphic file with name nihms847875t16.jpg 25 55 ± 2
11c graphic file with name nihms847875t17.jpg >5000 54 ± 2 11p graphic file with name nihms847875t18.jpg 87 55 ± 2
11d graphic file with name nihms847875t19.jpg >5000 69 ± 4 11q graphic file with name nihms847875t20.jpg 164 60 ± 2
11e graphic file with name nihms847875t21.jpg 68 ND 11r graphic file with name nihms847875t22.jpg 152 28 ± 1
11f graphic file with name nihms847875t23.jpg 40 <1 11s graphic file with name nihms847875t24.jpg 486 54 ± 7
11g graphic file with name nihms847875t25.jpg 73 15 ± 2 11t graphic file with name nihms847875t26.jpg 10 57 ± 5
11h graphic file with name nihms847875t27.jpg 150 13 ± 1 11u graphic file with name nihms847875t28.jpg 12 36 ± 2
11i graphic file with name nihms847875t29.jpg 44 <1 11v graphic file with name nihms847875t30.jpg 58 63 ± 1
11j graphic file with name nihms847875t31.jpg 126 ND 11w graphic file with name nihms847875t32.jpg 52 20 ± 2
11k graphic file with name nihms847875t33.jpg 127 ND 11x graphic file with name nihms847875t34.jpg 88 53 ± 1
11l graphic file with name nihms847875t35.jpg 8 4.9 ± 0.5 11y graphic file with name nihms847875t36.jpg 55 5 ± 1
11m graphic file with name nihms847875t37.jpg 1163 19 ± 1