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Comparative potencies of 1,2,3,4-tetrahydro-1-isoquinolone-4-carboxanilide enantiomers.
| Cmpd. | [α]D25 c = 1 | EC50 (nM)a |
|---|---|---|
| 13i | −131 | 587 |
| 13i | +147 | 36 |
| 13h | −154 | 189 |
| 13h | +152 | 21 |
| 11o | −175 | 477 |
| 11o | +159 | 15 |
Concentration causing 50% reduction in growth of P falciparum 3D7 co-cultured with human erythrocytes; values shown are from two independent experiments done in triplicate.
