Table 4. Changing patterns of immunosuppression according to causes.
| Cause of Change | The Most Common Pattern (n) | The 2nd Most Common Pattern (n) |
|---|---|---|
| Gastrointestinal adverse event | MMF to EC-MPS (72) | MPA withdrawal (29) |
| Infection | MPA withdrawal (83) | SRL conversion (8) |
| Bone marrow suppression | MPA withdrawal (22) | Steroid withdrawal (4) |
| Dose of simplicity | SRL conversion (16) | CSA to TAC (1) |
| Acute rejection | SRL conversion (4) | CSA to TAC (3) |
| Hair loss | TAC to CSA (8) | MMF to EC-MPS (7) |
| nephrotoxicity | SRL conversion (7) | CSA to TAC (1) |
| DM complications | Steroid withdrawal (3) | TAC to CSA (2) |
| malignancy | SRL conversion (3) | MPA withdrawal (1) |
| cardiovascular toxicity | MPA withdrawal (2) | CNI withdrawal (1) |
| others | MPA withdrawal (17) | Steroid withdrawal (13) |
Data account for the number (%) of immunosuppression changing pattern; total number = 396.
Abbreviation: GI, gastrointestinal; MMF, mycophenolic mofetil; EC-MPS, enteric-coated mycophenolate sodium; MPA, mycophenolic acid; SRL, sirolimus; CNI, calcineurin inhibitor; CSA, cyclosporine A; TAC, tacrolimus.