Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Aug 25;7:9502. doi: 10.1038/s41598-017-09858-y

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Predicted structure of PhoCHSA and selected CHS enzymes identified from other insects using TMHMM-2.0. (A) Topology of PhoCHSA showing the three major structural domains and associated structures and motifs. TMH: transmembrane helix, TMS: transmembrane span, N: N-terminus and C: C-terminus. Vertical bars represent the transmembrane regions while horizontal lines represent inner (lower) and outer (upper) domains. (B) Topology of selected CHS proteins showing the location of the catalytic domain and the SWGTR motif (indicated by arrow). Catalytic domains of SeCHSA (AAZ03545), SeCHSB (ABI96087), PxCHSB (XP_011565203) and AngCHSB (AGAP001205-PA) are located outside the plasma membrane while catalytic domains of PxCHSA (BAF47974), AngCHSA (AGAP001748), LcCHSA (AAG09712) and LcCHSB (KNC29062) are located inside the plasma membrane and facing the cytoplasm. Catalytic domain and SWGTR motif are always on opposite sides of the plasma membrane. Ang: Anopheles gambiae, Lc: Lucilia cuprina, Px: Plutella xylostella, Se: Spodoptera exigua.