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. 2017 Aug 25;7:9556. doi: 10.1038/s41598-017-09695-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of TQ-6 on ERK2, JNK1, p38 MAPK, and Akt phosphorylation in collagen-activated platelets. Washed platelets (1.2 × 10⁹ cells/ml) were preincubated with 0.3 or 0.5 μM TQ-6 or the solvent control (0.5% DMSO) and subsequently treated with 1 μg/ml collagen to induce platelet activation. Platelets were collected, and their subcellular extracts were analyzed to determine the levels of (A) ERK2, (B) JNK1, (C) p38 MAPK, and (D) Akt phosphorylation. Data are presented as means ± standard errors of the means (n = 4). *p < 0.05, **p < 0.01, and ***p < 0.001, compared with the solvent control (0.5% DMSO) group; ^#p < 0.05, ^##p < 0.01, and ^###p < 0.001, compared with the collagen-treated group.