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6-OHDA induces cyclooxygenase-2 (COX-2) expression. Neuro-2a cells (A) and SH-SY5Y cells (B) were treated with 6-OHDA at different concentrations (75 or 150 µM) for 0, 6 or 24 hr. COX-2 mRNA levels in these cells were measured by qPCR (*P < 0.05; **P < 0.01 compared to control, one-way ANOVA with post-hoc Dunnett’s Multiple Comparison Test). Data are presented as mean + SEM [n = 5–9 for Neuro-2a cells (A); n = 7 for SH-SY5Y cells (B)].
