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. 2017 Aug 25;7:9411. doi: 10.1038/s41598-017-09779-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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DDX3 localizes to the centrosome throughout the cell cycle and associates with p53 at centrosome during anaphase and telophase. HCT116 cells were immunostained with anti-DDX3 (red), anti-γ-tubulin (green), anti-p53 (blue) antibodies and DAPI (gray) during interphase (a-single centrosome; b-duplicated centrosomes), mitosis (c-metaphase; d-anaphase; e-telophase) and cytokinesis (f). Insets show higher magnifications of the centrosome (interphase, mitosis) and midbody (cytokinesis), respectively. Representative confocal images show colocalization of DDX3 with the centrosome in interphase and mitotic cells, and association of p53 with DDX3 and centrosome at anaphase and telophase. Additionally, DDX3 is concentrated at the midbody during cytokinesis. Scale bar = 5 μm.