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. 2017 Aug 25;7:9467. doi: 10.1038/s41598-017-09908-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Heat map representing (a) known metabolites significantly (p < 0.05) different between diabetic and healthy control dog groups and (b) top 50 known and unknown metabolites significantly (p < 0.05) different between groups. Group is indicated at the top of the figure by red (diabetic, n = 6) or green (healthy, n = 6). Individual dog breed corresponding to column is indicated at the bottom of the figure. Data was sum normalized, log transformed and autoscaled.