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. 2017 Aug 25;7:9409. doi: 10.1038/s41598-017-09797-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Treatment with Sofosbuvir increases survival and inhibits weight loss of ZIKV-infected mice. Three-day-old Swiss mice were infected with ZIKV (2 × 10⁷ PFU) and treated with sofosbuvir either 1 day before (A and B) or 2 days after infection (C and D). Survival (A and C) and weight variation (B and D) were assessed during the course of treatment (7 days). The red arrow indicates when animals were infected. Survival was statistically assessed by Log-rank (Mentel-Cox) test. Differences in weight are displayed as the means ± SEM, and two-way ANOVA for each day was used to assess the significance. Independent experiments were performed with at least 10 mice/group (n = 50). *P < 0.01; **P < 0.001.