Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Aug 25;7:9409. doi: 10.1038/s41598-017-09797-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Sofosbuvir prevents memory loss in animals that survive ZIKV infection. Animals that survived from ZIKV neonatal infection, untreated or pretreated with sofosbuvir, were kept and tested for behavioural sequelae in learning and memory after 60 days. The time to find the platform, according to MWM test, was assessed. Trial in the absence of the platform was conducted (A) (*P < 0.05, Student’s t test). In panel A, latency represents the time spent exploring the quadrant where the platform was located before removal, and the data are expressed as the means ± SEM (n = 5 to 8 per experimental group). Aversive memory was evaluated by freezing behaviour 24 h post-training session, whereas mice were allowed to explore the aversive environment during 180 s followed by two foot shocks (0.6 mA, 3 s) (B). In panel B, latency represents the time spent without movement (freezing) during 180 s, and the data are expressed as the means ± SEM (n = 5 to 8 per experimental group).