Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Aug 25;7:9482. doi: 10.1038/s41598-017-09865-z

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

miR-221/222 expression is modulated by SOCS1/Met axis and is associated with acute obstructive cholangitis prognosis. (A) Determination of HGF levels in liver tissues from AOC rats with different prognosis. (B) Relative expression of miR-221 and miR-222 in liver tissues from different rat models. n = 6 each group, *P < 0.05; **P < 0.01 versus sham group. ^&& P < 0.01 versus LPS group. ^$ P < 0.05 versus BDL group. (C) Relative expression of miR-221 and miR-222 in liver tissues from AOC rats with different prognosis. (D) Determination of the relationship between SOCS1 and Met protein levels by western blot analysis. (E and F) Determination of relative miR-221/222 levels under the condition of aberrant SOCS1 expression in vitro, three assays were performed. (G and H) Correlation coefficients (R) between the mRNA levels of SOCS1 and miR-221/222 were respectively calculated in liver tissue samples from AOC rats. (I) Cell proliferation assays released that silencing of SOCS1 significantly promotes proliferation of BRL cells in vitro. NBD, the rats without biliary drainage. BD-death, the rats with biliary drainage and died in the 72-h observation period after LPS infusion. BD-survival, the rats with biliary drainage and survived in the 72-h observation period. ^# P < 0.05; ^## P < 0.01; significant difference between the two groups. N.S. = non-significant, between the two groups.