Table 2.
Summary of pepcan-12 modulation of CP55,940- and 2-AG-induced G protein activation and cAMP formation.
| [35S]GTPγS assay | cAMP assay | |||||
|---|---|---|---|---|---|---|
| CP55,940 | 2-AG | CP55,940 | 2-AG | |||
| Pepcan-12 (nM) | EC50 (nM) | Max. Effect (% of crtl) | EC50 (nM) | Max. Effect (% of crtl) | EC50 (nM) | EC50 (nM) |
| 0 | 3.5 (2.8–6.2) | 234 (222–246) | 95.8 (66–145) | 235 (220–251) | 3.1 (1.8–6.7) | 92.1 (40–102) |
| 10 | 3.4 (1.2–8.1) | 242 (214–271) | 64.9 (32–130) | 238 (221–251) | 4.1 (1.6–9.1) | 102.1 (55–225) |
| 30 | 2.9 (2.2–5.5) | 259 (247–274) | 40.9 (20–61) | 254 (237–272) | 0.9 (0.6–1.3) | 25.1 (12–38) |
| 100 | 1.4 (0.6–2.7) | 260 (249–276) | 35.4 (16–54) | 291 (265–318) | 1.0 (0.6–1.5) | 12.4 (4–34) |
n = 6–12; data show means values and 95% CI. *p < 0.05; **p < 0.001.