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. 2017 Aug 25;7:9429. doi: 10.1038/s41598-017-09819-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Diagram of P53 signaling pathway with overlaid molecular activity prediction after heat stress. Diagram of canonical P53 signaling pathway showing up (red) and down (green) regulated genes immediately after heat stress (T1) (a), and one hour after heat stress (T2) (b) along with predictions on biological function. Cell survival and glycolysis (colored orange) are predicted to be increased, while apoptosis, autophagy, senescence, DNA repair, and mitochondrial respiration (colored blue) are predicted to be decreased at both time points. Cell cycle progression is predicted to be increased at T2 only after heat stress (b). The pathway and the molecular activity prediction analyses were generated through the use of QIAGEN’s Ingenuity Pathway Analysis (IPA^®, QIAGEN Redwood City, www.qiagen.com/ingenuity).