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. 2017 Aug 11;174(18):3081–3093. doi: 10.1111/bph.13942

Figure 4.

Figure 4

Effect of dofetilide and derivatives on potassium currents mediated through hERG channels expressed in HEK293 cells. (A) Representative current traces of control current (in the absence of drug) and in the presence of Dofe54 after steady state was reached at each concentration applied. The voltage protocol illustrated was applied every 3 s (A, upper panel). (B) Concentration‐inhibition curves for dofetilide (n = 5) and high affinity derivatives: Dofe54 (n = 5), Dofe81 (n = 6), Dofe60 (n = 5), Dofe78 (n = 7), Dofe35 (n = 8), Dofe45 (n = 5) and Dofe44 (n = 6). (C) Concentration‐inhibition curves for dofetilide and low affinity derivatives: Dofe33 (n = 6), Dofe31 (n = 7), Dofe30 (n = 7), Dofe41 (n = 8), Dofe42 (n = 8) and Dofe43 (n = 5). Peak tail current values (mean ± SEM, see Table 2) were fitted by the Hill equation.