Table 1.
Changes in APD90 in hiPSC‐CMs after application of dofetilide and derivatives
| Compound | 0.1 nM | 1 nM | 10 nM | 30 nM | 100 nM | 300 nM | 1000 nM |
|---|---|---|---|---|---|---|---|
| Dofetilide | 191(n = 6) | 246(n = 4) | 641(n = 4) | 827(n = 4) | 1032(n = 5) | – | – |
| Dofe54 | – | 107(n = 4) | 651(n = 4) | 702(n = 4) | 710(n = 4) | – | – |
| Dofe81 | – | 117(n = 4) | 389(n = 4) | 858(n = 4) | 1048(n = 5) | – | – |
| Dofe60 | – | 95(n = 4) | 112(n = 4) | 185(n = 6) | 771(n = 4) | 413(n = 6) | – |
| Dofe35 | – | 102(n = 4) | 159(n = 4) | 770(n = 4) | 746(n = 4) | 650(n = 5) | – |
| Dofe78 | – | – | 116(n = 4) | – | 420(n = 4) | 300(n = 4) | 417(n = 4) |
| Dofe45 | – | – | 71(n = 4) | – | 89(n = 4) | 95(n = 4) | 215(n = 4) |
| Dofe33 | – | 122(n = 4) | 96(n = 4) | 101(n = 4) | 112(n = 4) | 177(n = 4) | 263(n = 4) |
| Dofe31 | – | 127(n = 4) | 100(n = 4) | 103(n = 4) | 108(n = 4) | 214(n = 4) | 296(n = 4) |
| Dofe30 | – | – | 99(n = 4) | 92(n = 4) | 105(n = 4) | 190(n = 4) | 140(n = 4) |
| Dofe41 | – | – | 140(n = 6) | – | 144(n = 5) | 162(n = 5) | 262(n = 4) |
| Dofe42 | – | – | 113(n = 4) | – | 92(n = 4) | 95(n = 4) | 98(n = 4) |
| Dofe43 | – | – | 167(n = 5) | – | 156(n = 5) | 175(n = 5) | 390(n = 4) |
| Dofe44 | – | – | 90(n = 4) | – | 83(n = 4) | 87(n = 4) | 92(n = 4) |
The values are presented as a % of control.