Figure 2.

Effects of prophylactic AQX‐1125 on bleomycin‐induced cell influx, myeloperoxidase activity (MPO) and pulmonary oedema. Mice were treated prophylactically with either saline vehicle (sal, p.o., daily), AQX‐1125 (3, 10 or 30 mg·kg⁻¹·d⁻¹, p.o.) or dexamethasone (dex, 1 mg·kg⁻¹·d⁻¹, i.p.) for 3 days prior to receiving a single intratracheal administration of bleomycin (BLM). The sham‐treated group received intratracheal saline. Cells recovered from the bronchoalveolar lavage fluid on Day 7 (A) and Day 21 (B) were counted by haemocytometry. MPO activity was measured in homogenized lung tissue on Day 7 (C) and Day 21 (D). Lung oedema at Day 7 (E) and Day 21 (F) was measured as a ratio of wet to dry weight of excised lung tissue. *P < 0.05, significantly different from vehicle. Results are given as mean ± SEM from n = 5–15 (surviving animals from bleomycin‐treated groups) or n = 5 (sham‐treated group).