Table 2.
Neutrophils (×106) | Macrophages (×106) | Lymphocytes (×106) | |
---|---|---|---|
Sham | 0.00 ± 0.00* | 0.18 ± 0.01* | 0.00 ± 0.00* |
Bleomycin | 0.30 ± 0.02 | 0.60 ± 0.02 | 0.10 ± 0.00 |
AQX‐1125 3 mg·kg−1 | 0.28 ± 0.02 | 0.54 ± 0.02* | 0.09 ± 0.00* |
AQX‐1125 10 mg·kg−1 | 0.13 ± 0.01* | 0.39 ± 0.01* | 0.05 ± 0.00* |
AQX‐1125 30 mg·kg−1 | 0.05 ± 0.00* | 0.26 ± 0.01* | 0.03 ± 0.00* |
Pirfenidone 90 mg·kg−1 | 0.05 ± 0.00* | 0.25 ± 0.01* | 0.03 ± 0.00* |
Data are the mean ± SEM of the absolute leukocyte counts (×106 cells) (n = 10–29).
P < 0.05 shows a significant effect of AQX‐1125 or pirfenidone, compared to the vehicle‐treated bleomycin group.