Table 1.
Baseline characteristics of the FAVORIT sub-cohort, overall and by cystatin C-based estimated glomerular filtration rate (eGFRcys) group.
| Characteristics | Overall | eGFRcys Group (mL/min/1.73m2) | |||
|---|---|---|---|---|---|
| <30 | 30 to <45 | 45 to <60 | 60+ | ||
| N | 508 | 96 | 207 | 125 | 80 |
| Age | 51.6 (9.2) | 52.0 (8.7) | 52.6 (9.7) | 51.0 (8.9) | 49.4 (8.6) |
| Women | 193 (38.0%) | 40 (41.7%) | 83 (40.1%) | 42 (33.6%) | 28 (35.0%) |
| Race | |||||
| White | 388 (76.4%) | 70 (72.9%) | 157 (75.9%) | 97 (77.6%) | 64 (80%) |
| Black | 87 (17.1%) | 16 (16.7%) | 39 (18.8%) | 21 (16.8%) | 11 (13.75%) |
| Other | 33 (6.5%) | 10 (10.4%) | 11 (5.3%) | 7 (5.6%) | 5 (6.25%) |
| Treatment Group | |||||
| High Dose Vitamin | 253 (49.8%) | 47 (48.96%) | 110 (53.1%) | 58 (46.4%) | 38 (47.5%) |
| Low Dose Vitamin | 255 (50.2%) | 49 (51.0%) | 97 (46.9%) | 67 (53.6%) | 42 (52.5%) |
| Country | |||||
| United States | 348 (68.5%) | 63 (65.6%) | 142 (68.6%) | 88 (70.4%) | 55 (68.75%) |
| Canada | 69 (13.5%) | 13 (13.5%) | 24 (11.6%) | 14 (11.2%) | 18 (22.5%) |
| Brazil | 91 (17.9%) | 20 (20.8%) | 41 (19.8%) | 23 (18.4%) | 7 (8.75%) |
| Graft vintage (yr), median (25th, 75th) |
4 [2, 7] | 5 [2, 9] | 4 [2, 7] | 3 [1, 5] | 4 [2, 7] |
| Living donor kidney (%) | 214 (42.1%) | 28 (29.2%) | 83 (40.1%) | 67 (53.6%) | 36 (45.0%) |
| History of cardiovascular disease (%) | 96 (18.9%) | 25 (26.0%) | 37 (17.9%) | 25 (20.0%) | 9 (11.25%) |
| History of diabetes mellitus (%) | 184 (36.2%) | 38 (39.6%) | 69 (33.3%) | 53 (42.4%) | 24 (30.0%) |
| Smoking (%) | |||||
| Never | 254 (50.0%) | 48 (50%) | 100 (48.3%) | 62 (49.6%) | 44 (55.0%) |
| Current | 56 (11.0%) | 15 (15.6%) | 26 (12.6%) | 10 (8.0%) | 5 (6.25%) |
| Former | 192 (37.8) | 32 (33.3%) | 79 (38.2%) | 51 (40.8%) | 30 (37.5%) |
| Body mass index (kg/m2) | 28.9 (5.9) | 29.2 (5.7) | 29.6 (6.4) | 28.6 (5.5) | 27.2 (4.9) |
| SBP (mm Hg) | 136 (20) | 138 (24) | 136 (20) | 137 (19) | 129 (17) |
| DBP (mm Hg) | 79 (13) | 80 (14) | 80 (14) | 79 (10) | 78 (11) |
| Total Cholesterol (mg/dL) | 188 (43) | 190 (51) | 188 (44) | 186 (38) | 187 (35) |
| LDL cholesterol (mg/dL) | 103 (33) | 102 (37) | 103 (33) | 104 (32) | 104 (31) |
| HDL cholesterol (mg/dL) | 47 (14) | 42 (16) | 47 (13) | 47 (14) | 50 (15) |
| Triglycerides (mg/dL) | 167 [114, 243] | 189 [142, 274] | 167 [117, 240] | 155 [107, 229] | 133 [96, 219] |
| Creatinine (mg/dL) | 1.8(0.6) | 2.4 (0.7) | 1.9 (0.6) | 1.5 (0.3) | 1.3 (0.3) |
| Cystatin C (mg/L) | 1.5 (0.4) | 2.2 (0.3) | 1.6 (0.1) | 1.2 (0.1) | 1.0 (0.1) |
| B2M (mg/L) | 3.8 (1.8) | 6.5 (2.1) | 3.8 (1.0) | 2.8 (0.6) | 2.2 (0.4) |
| eGFRcr (mL/min/1.73m2) | 46.0 (18.2) | 30.7 (12.3) | 41.4 (13.2) | 54.8 (15.2) | 62.8 (19.4) |
| eGFRcys (mL/min/1.73m2) | 43.8 (15.0) | 26.1 (5.9) | 38.4 (7.1) | 52.5 (7.7) | 65.5 (11.5) |
| eGFRB2M (mL/min/1.73m2) | 48.8 (16.4) | 28.8 (6.9) | 44.4 (8.9) | 57.2 (9.9) | 71.1 (12.8) |
| Urine Albumin to Creatinine Ratio (mg/g) | 25 [10, 110] | 64 [18, 435] | 29 [10, 112] | 15 [7, 47] | 16 [8, 58] |
Note: Continuous variables are presented as mean (standard deviation) or as median [25th percentile, 75th percentile].