Table 2.
Association of filtration markers with risk of adjudicated cardiovascular events (N=306 events) in stable kidney transplant recipients in FAVORIT
| Demographic and Transplant Characteristic Adjusted* | Multivariable Adjusted^ | Multivariable Adjusted^ + eGFRcr | ||||
|---|---|---|---|---|---|---|
| HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | |
| eGFRcys | ||||||
| <30 | 3.58 (2.08, 6.15) | <0.001 | 2.02 (1.09, 3.76) | 0.03 | 3.05 (1.41, 6.57) | 0.005 |
| 30 to <45 | 1.78 (1.07, 2.97) | 0.03 | 1.56 (0.89, 2.77) | 0.13 | 2.09 (1.07, 4.06) | 0.03 |
| 45 to <60 | 1.32 (0.75, 2.29) | 0.33 | 0.93 (0.49, 1.79) | 0.83 | 1.04 (0.54, 2.02) | 0.90 |
| 60+ | Reference | – | Reference | – | Reference | – |
| p-trend | <0.001 | p-trend | 0.03 | p-trend | 0.008 | |
| per 10 mL/min/1.73m2 | 0.72 (0.63, 0.82) | <0.001 | 0.78 (0.68, 0.90) | <0.001 | 0.68 (0.56, 0.83) | <0.001 |
| eGFRB2M | ||||||
| <30 | 3.66 (2.19, 6.13) | <0.001 | 2.56 (1.35, 4.88) | 0.004 | 3.16 (1.54, 6.50) | 0.002 |
| 30 to <45 | 2.10 (1.34, 3.29) | 0.001 | 1.71 (0.96, 3.03) | 0.07 | 1.99 (1.06, 3.74) | 0.03 |
| 45 to <60 | 1.39 (0.87, 2.23) | 0.17 | 1.16 (0.64, 2.08) | 0.63 | 1.24 (0.68, 2.24) | 0.48 |
| 60+ | Reference | – | Reference | – | Reference | – |
| p-trend | <0.001 | p-trend | 0.01 | p-trend | 0.006 | |
| per 10 mL/min/1.73m2 | 0.75 (0.67, 0.83) | <0.001 | 0.80 (0.70, 0.91) | <0.001 | 0.74 (0.63, 0.87) | 0.003 |
| eGFRcr | ||||||
| <30 | 1.26 (0.78, 2.05) | 0.34 | 1.16 (0.66, 2.03) | 0.61 | – | – |
| 30 to <45 | 1.51 (0.97, 2.34) | 0.07 | 1.29 (0.76, 2.18) | 0.34 | – | – |
| 45 to <60 | 0.84 (0.52, 1.34) | 0.45 | 0.83 (0.48, 1.44) | 0.51 | – | – |
| 60+ | Reference | – | Reference | – | – | – |
| p-trend | 0.02 | p-trend | 0.32 | – | – | |
| per 10 mL/min/1.73m2 | 0.94 (0.86, 1.03) | 0.20 | 0.96 (0.88, 1.06) | 0.46 | – | – |
Note: Weighted Cox regression models were performed in the cardiovascular events analytic sample of 760 participants with 306 events. Results in the shaded area are not presented because models with eGFRcr as the primary exposure cannot be additionally adjusted for eGFRcr.
Adjusted for age, sex, race, country, randomized treatment assignment, donor type, graft vintage
Adjusted for age, sex, race, country, randomized treatment assignment, donor type, graft vintage, prevalent cardiovascular disease, diabetes, smoking status, LDL cholesterol, HDL cholesterol, triglycerides, systolic blood pressure, diastolic blood pressure, body mass index, and natural log transformed urinary albumin to creatinine ratio.