Table 3.

Factors associated with worse overall survival according to univariate and multivariate analysis

Variables	PMF	PPV-MF	PET-MF
Univariate analysis	p-value, HR [95 % CI]	p-value, HR [95 % CI]	p-value, HR [95 % CI]
Age>65 years	<0.001, 1.88 [1.5–2.3]	0.005, 1.82 [1.20–2.77]	--
Hemoglobin below 10	0.03, 1.2 [1.02–1.5]	0.007, 1.75 [1.17–2.63]	0.007, 1.9 [1.19–3.10]
Platelets below 100	<0.001, 1.4 [1.1–1.7]	0.003, 1.9 [1.24–2.94]	<0.001, 6.75 [3.33–13.7]
Peripheral blasts >1%	0.002, 1.4 [1.1–1.6]	0.07, NA	<0.001, 3.3 [2.0–5.4]
Symptoms	<0.001, 1.6 [1.3–2.03]	0.005, 2.28 [1.29–4.06]	0.013, 1.8 [1.13–2.88]
Abn Unfavorable CG*	0.012; 1.3 [1.07–1.67]	--	0.04, 1.81 [1.03–3.21]
Multivariate analysis
Age>65 years	<0.001, 1.87 [1.5–2.3]	0.046, 1.58 [1.01–2.49]	--
Hemoglobin below 10	0.031, 1.27 [1.02–1.58]	0.008, 1.81 [1.17–2.78]	--
Platelets below 100	0.032, 1.27 [1.02–1.59]	--	<0.001, 4.63 [2.18–6.80]
Peripheral blasts >1%	0.004, 1.35 [1.10–1.65]	--	<0.001, 2.83 [1.64–4.88]
Presence of symptoms	<0.001, 1.53 [1.20–1.95]	0.003, 2.56 [1.37–4.79]	--

All variables are categorical, symptoms are defined according to IWG criteria;

^*Abn unfavorable cytogenetic = abnormalities other than single deletion 13q, or 20q, and abnormality of chromosome 9;

^--not statistically significant.