The gut is the starter and the liver is the motor of MOF. Complement factors C3a and C5a; PGE2, prostaglandin E2; IL-1, interleukin-1; O2−, superoxide radical; ATN, acute tubular necrosis; ARDS, acute respiratory distress syndrome. (Reprinted with permission of Wolters Kluwer Health, Inc, from Moore FA, Moore EE, Jones TN, McCroskey BL, Peterson VM. TEN versus TPN Following Major Abdominal Trauma – Reduced Septic Morbidity. J Trauma.1989; volume 29, issue 7:916–23).