Table 6.
Sex-specific associations of branched chain amino acids (BCAA) with MetRisk z-score nad its components among 238 ELEMENT adolescents.
| β (95% CI) for each biomarker per 1 unit increment in metabolite z scorea | |||||||
|---|---|---|---|---|---|---|---|
| Mean ± SD metabolite | Waist circumference | Fasting glucose | Fasting C peptide | Triglyceride:HDL ratio | (SBP + DBP)/2 | MetRisk z score | |
| z-scoreb | cm | mg/dL | ng/mL | mmHg | |||
|
|
|
||||||
| Girls (n = 125) | |||||||
| Leucine | 0.04 ± 0.91 | 0.0 (−2.1, 2.2) | −1.1 (−3.2, 1.0) | 0.0 (−0.2, 0.2) | 0.1 (−0.1, 0.3) | −0.1 (−1.7, 1.4) | −0.01 (−0.13, 0.11) |
| Isoleucine | −0.02 ± 0.93 | 0.9 (−1.2, 3.0) | 0.0 (−2.0, 2.1) | 0.1 (−0.2, 0.3) | 0.2 (0.0, 0.4) | −0.3 (−1.8, 1.2) | 0.05 (−0.06, 0.16) |
| Valine | 0.06 ± 0.93 | 1.3 (−0.7, 3.4) | −0.5 (−2.5, 1.6) | 0.1 (−0.1, 0.4) | 0.3 (0.1, 0.5) | −0.1 (−1.6, 1.4) | 0.09 (−0.03, 0.20) |
| Boys (n = 113) | |||||||
| Leucine | −0.01 ± 1.09 | 3.0 (1.4, 4.5) | −0.8 (−2.2, 0.6) | 0.3 (0.2, 0.5) | 0.0 (−0.1, 0.2) | 1.2 (−0.1, 2.6) | 0.13 (0.03, 0.24) |
| Isoleucine | 0.04 ± 1.08 | 3.1 (1.5, 4.8) | −1.3 (−2.7, 0.2) | 0.2 (0.0, 0.4) | 0.0 (−0.1, 0.2) | 0.8 (−0.6, 2.2) | 0.10 (−0.01, 0.21) |
| Valine | −0.07 ± 1.07 | 2.4 (0.7, 4.0) | −0.8 (−2.2, 0.7) | 0.3 (0.1, 0.5) | 0.1 (−0.1, 0.2) | 1.4 (−0.1, 1.9) | 0.14 (0.03, 0.24) |
a
Adjusted for maternal education, and child’s sex and pubertal status.
Bolded estimates indicate statistical significance at P <0.05.