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. Author manuscript; available in PMC: 2018 Sep 1.
Published in final edited form as: Am J Transplant. 2017 Apr 18;17(9):2326–2337. doi: 10.1111/ajt.14266

Figure 5. Effective suppression of IRI induced chronic rejection with anti-IL6 nanoparticles.

Figure 5

A) Representative TEM image of PLGA-NPs stained with 0.75% uranyl formate (scale bar 100 nm). B) Size distribution of anti-IL6 loaded PLGA-NPs measured by dynamic light scattering. C) NP-anti-IL6 significantly suppressed T cell proliferation in anti-CD3/CD28 T cell proliferation assay (*p<0.05 and **p<0.01). D) Fluorescent-labeled particles perfused through the hearts prior to transplantation were still detectable in grafts on day 7 post-transplant. E) NP-anti-IL6 treatment of ischemic heart prior to transplant significantly reduces chronic rejection as compare to ischemic control and less CD3 and F4/80. Original magnification: 100×. TEM: Transmission electron microscopy.